Direktkontakt
TransMIT-Zentrum für Pharmakogenetische Diagnostik (PGvet)
Prof. Dr. Joachim Geyer
c/o Justus-Liebig-Universität Gießen
Institut für Pharmakologie und Toxikologie
Schubertstr. 81
35392 Gießen
Telefon: +49 (6 41) 99 38 411
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Referenzen
Geyer J, Döring B, Godoy JR, Moritz A, Petzinger E (2005) Development of a PCR-based diagnostic test detecting a nt230(del4) MDR1 mutation in dogs: verification in a moxidectin-sensitive Australian Shepherd. Journal of Veterinary Pharmacology and Therapeutics, 28(1):95-99.
Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2004.00625.x
Geyer J, Döring B, Godoy JR, Leidolf R, Moritz A, Petzinger E (2005) Frequency of the nt230(del4) MDR1 mutation in Collies and related dog breeds in Germany. Journal of Veterinary Pharmacology and Therapeutics, 28(6):545-551.
Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2005.00692.x
Linek J, Spiess B, Dallmeyer C, Geyer J (2007) Ivermectin intoxication in three dogs with and without MDR1 gene mutation caused by vermicide paste licensed for use in horse. Tierärztliche Praxis Ausgabe Kleintiere Heimtiere, 35(4):272-278.
Link: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1622602
Geyer J, Klintzsch S, Meerkamp K, Wöhlke A, Distl O, Moritz A, Petzinger E (2007) Detection of the nt230(del4) MDR1 mutation in White Swiss Shepherd dogs: case reports of doramectin toxicosis, breed predisposition, and microsatellite analysis. Journal of Veterinary Pharmacology and Therapeutics, 30(5):482-485.
Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2007.00885.x
Geyer J, Gavrilova O, Petzinger E (2008) Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein and bcrp deficient knockout mice. Journal of Veterinary Pharmacology and Therapeutics, 32: 87-96.
Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2008.01007.x
Geyer J, Gavrilova O, Petzinger E (2009) The role of P-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride. Drug Metabolism and Disposition, 37:1371-1374.
Link: https://dmd.aspetjournals.org/content/37/7/1371.long
Klintzsch S, Meerkamp K, Döring B, Geyer J (2009) Detection of the nt230(del4) MDR1 mutation in dogs by a fluorogenic 5’ nuclease TaqMan allelic discrimination method. The Veterinary Journal, 185:272-277.
Link: https://www.sciencedirect.com/science/article/pii/S1090023309002913?via%3Dihub
Gramer I, Leidolf R, Döring B, Klintzsch S, Krämer EM, Yalcin E, Petzinger E, Geyer J (2011) Breed distribution of the nt230(del4) MDR1 mutation in dogs. The Veterinary Journal, 189: 67-71.
Link: https://www.sciencedirect.com/science/article/pii/S1090023310002261?via%3Dihub
Held S, Gramer I, Hassdenteufel E, Neiger R, Geyer J (2012) Therapie einer Avermectin-Intoxikation bei zwei Hunden mit homozygotem nt230(del4)- MDR1-Gendefekt durch Lipidinfusion. Kleintierpraxis 57(6):313-319.
Link: https://www.vetline.de/therapie-einer-avermectin-intoxikation-bei-zwei-hunden-mit-homozygotem-nt230del4-mdr1-gendefekt
Geyer J, Janko C (2012) Treatment of MDR1 mutant dogs with macrocyclic lactones.Current Pharmaceutical Biotechnology 13:969-986.
Link: https://www.eurekaselect.com/96885/article
Janko C, Geyer J (2013) Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin. Journal of Veterinary Pharmacology and Therapeutics 36:275-284.
Link: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2012.01424.x
Elmshäuser S, Wilke A, Geyer J (2014) Arzneimittelunverträglichkeiten nach Gabe von Emodepsid/Praziquantel (Profender®) bei Hunden mit MDR1-Gendefekt. Kleintierpraxis 59(11):597-605.
Link: https://www.vetline.de/arzneimittelunvertraeglichkeiten-nach-gabe-von-emodepsidpraziquantel-profenderr-bei-hunden-mit-mdr1
Elmshäuser S, Straehle LC, Kranz J, Krebber R, Geyer J (2015) Brain penetration of emodepside is increased in P-glycoprotein-deficient mice and leads to neurotoxicosis. Journal of Veterinary Pharmacology and Therapeutics 38:74-79.
Link: https://onlinelibrary.wiley.com/doi/10.1111/jvp.12149
Gramer I, Kessler M, Geyer J (2015) Determination of MDR1 gene expression for prediction of chemotherapy tolerance and treatment outcome in dogs with lymphoma. Veterinary and Comparative Oncology 13(4): 363-372.
Link: https://onlinelibrary.wiley.com/doi/10.1111/vco.12051
Gäns D, Rummel C, Schmidt M, Hamann M, Geyer J (2019) Suspected neurological toxicity after oral application of fluralaner (Bravecto®) in a Kooikerhondje dog. BMC Veterinary Research 15(1):283
Link: https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-019-2016-4
Gäns D, Leithäuser C, Hamann M, Geyer J (2019) Adverse drug reactions after administration of emodepside/praziquantel (Profender®) in an MDR1-mutant Australian Shepherd dog: case report. Frontiers in Veterinary Science 6:296.
Link: https://www.frontiersin.org/articles/10.3389/fvets.2019.00296/full
Nürnberger D, Müller SF, Hamann M, Geyer J (2021) First sequencing of caprine Mdr1 (Abcb1) mRNA due to suspected neurological adverse drug reaction in a Thuringian goat following extra-label use of doramectin. Frontiers in Veterinary Science 8:682393.
Link: https://www.frontiersin.org/articles/10.3389/fvets.2021.682393/full
Geyer J (2021) Personalisierte Medizin in der Pharmakotherapie: Wie weit sind wir in der Veterinärmedizin? Kleintier konkret 24(02):20-30.
Link: https://www.researchgate.net/publication/350984018_Personalisierte_Medizin_in_der_Pharmakotherapie_Wie_weit_sind_wir_in_der_Veterinarmedizin
Nürnberger D, Wagner L, Müller SF, Leiting S, Leidolf R, Alber J, Hamann M, Geyer J (2021) Detection of the ABCB11930_1931del TC mutation in two suspected ivermectin-sensitive cats and their relatives by a novel TaqMan allelic discrimination assay. Frontiers in Veterinary Science 8:808392.
Link: https://www.frontiersin.org/articles/10.3389/fvets.2021.808392/full
Müller E, Geyer J (2021) Berücksichtigung des MDR1-Defekts beim Hund für die Anwendung von Anästhetika. Der Praktische Tierarzt 102:1051-1066.
Link: dpt10_sonderdruck-fortbildung_scr.pdf